ISIS Neutron and Muon Source Data Journal

Internal structure of chitosan and modified chitosan nanoparticles for transmucosal drug delivery

Abstract: Mucus is a viscoelastic gel present on various moist surfaces of human body including gastrointestinal tract, eyes, respiratory system, bladder and vagina. Administration of drugs via mucosal membranes offers a number of advantages as it can be used as an alternative to injections and sometimes gives an opportunity to deliver medication directly to the target organ. However, the mucus gel often acts as a barrier for successful drug delivery; it can trap drug molecules before they are able to reach surface cells and achieve therapeutic effects. The aim of our research is to develop nanoparticles capable of crossing mucosal membranes efficiently. We will use neutron scattering to probe the structure of these nanoparticles to understand how their structural features could affect their diffusivity through mucosal membranes.

Principal Investigator: Professor Vitaliy Khutoryanskiy
Experimenter: Dr Daulet Kaldybekov
Experimenter: Dr Anastasiia Murmiliuk
Local Contact: Dr Steve King
Experimenter: Mr Twana M.ways
Experimenter: Professor Sergej Filippov

DOI: 10.5286/ISIS.E.RB1810863

ISIS Experiment Number: RB1810863

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Vitaliy Khutoryanskiy et al; (2018): Internal structure of chitosan and modified chitosan nanoparticles for transmucosal drug delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810863

Data is released under the CC-BY-4.0 license.