ISIS Neutron and Muon Source Data Journal

Self-assembly of lipid and triblock copolymer-based amphiphiles for drug delivery

Abstract: Soft self-assembled structures have been extensively used as drug nanocarriers. Their building blocks, naturally occurring and synthetic amphiphiles (lipids or block copolymers), have been proven to offer a wide range of morphologies on the nanometre scale. Careful design of the amphiphiles’ molecular structure and composition allows for self-assembly or structural transition of such nanoconstructs upon external stimuli. Here, we propose a study to characterize the effect of composition and temperature on the self-assembly behaviour of phospholipids and temperature-responsive triblock copolymers. Besides answering fundamental questions on the structure morphology of such nanoconstructs, the results of this study will be particularly important for the design of novel drug nanocarriers with tunable morphology and versatile applicability over a wide range of projects within our group.

Principal Investigator: Dr Michael Thomas
Experimenter: Miss Lucia Massi
Experimenter: Dr Margaret Holme
Local Contact: Dr James Doutch
Experimenter: Professor Molly Stevens
Experimenter: Dr Hanna Barriga
Experimenter: Miss Valeria Nele

DOI: 10.5286/ISIS.E.RB1810203

ISIS Experiment Number: RB1810203

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Michael Thomas et al; (2018): Self-assembly of lipid and triblock copolymer-based amphiphiles for drug delivery, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810203

Data is released under the CC-BY-4.0 license.