ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Protein Adsorption at the PDMS Oil/Water Interface
Abstract: Neutron reflection has been successfully used to measure the conformation of proteins adsorbed at the oil/water interface. However, in several such experiments, hexadecane has been used as an oil substrate for cost and practicality reasons. Polydimethylsiloxane (PDMS) is widely used for medical applications in which protein adsorption is a key factor, such as drug storage and delivery. This experiment will examine whether hexadecane is a useful model substrate for PDMS, and thus whether it is suitable for future practical protein adsorption investigations. The adsorption of two proteins, bovine serum albumin, and the monoclonal antibody COE-3, will be investigated to determine if their behaviour is similar at both interfaces, and thus whether the hexadecane/water interface is a useful analogue for the PDMS/water interface.
Principal Investigator: Professor Jian Lu
Experimenter: Mr Haoning Gong
Experimenter: Dr Xuzhi Hu
Local Contact: Dr Mario Campana
Experimenter: Mr Sean Ruane
Experimenter: Dr Zongyi Li
Experimenter: Dr Lisa Pan
DOI: 10.5286/ISIS.E.RB1810229
ISIS Experiment Number: RB1810229
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.95665490 | INTER | 02 July 2021 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2018): Protein Adsorption at the PDMS Oil/Water Interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810229
Data is released under the CC-BY-4.0 license.
