ISIS Neutron and Muon Source Data Journal

Interplay of apoptosis regulating Bcl-2 proteins with mitochondrial membranes upon oxidative stress: Impact of oxidized lipids.

Abstract: Mitochondria are not only the powerhouse of the cell, but are also involved in cellular suicide via apoptosis (programmed cell death). The mitochondrial apoptotic pathway is a major regulator in mammalian cells death, where pro- and anti-survival Bcl-2 proteins meet at the mitochondrial outer membrane and tightly regulate the fate of a cell. Treatment-resistant tumour cells often possess mitochondria which are enriched in the pro-survival Bcl-2 membrane protein which blocks any apoptotic signals upon onset via oxidative stress. Our main aim is to generate by using neutron reflectometry fundamental knowledge about the membrane mediated function of the cell-death causing (anti-survival) Bax protein and its counterplayer, the pro-survival Bcl-2 membrane protein to regulate and execute apoptosis; information also useful for novel cancer strategies.

Principal Investigator: Professor Gerhard Groebner
Experimenter: Dr Hanna Wacklin-Knecht
Experimenter: Dr Tobias Sparrman
Experimenter: Dr Jörgen Ådén
Experimenter: Dr Luke Clifton

DOI: 10.5286/ISIS.E.RB1810627

ISIS Experiment Number: RB1810627

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Gerhard Groebner et al; (2018): Interplay of apoptosis regulating Bcl-2 proteins with mitochondrial membranes upon oxidative stress: Impact of oxidized lipids., STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810627

Data is released under the CC-BY-4.0 license.