ISIS Neutron and Muon Source Data Journal

Structure of oxidised phospholipid bilayers

Abstract: Biological membranes protect cells and are essential for their survival and damaged membranes may cause serious harm to the cell. A primary cause of damage to membranes is oxidation by radicals present in the body. The lipids which comprise the membrane are changed by oxidation and as a result so is the membrane structure. Insight into how lipid oxidation relates to structural changes in the membrane is an essential step to understand how membrane oxidation is related to diseases. By creating mixed bilayers of a phospholipid and varying amounts of an oxidised lipid and determining the structure with neutron reflectivity, we aim to understand how the structure of the bilayer is changed when oxidised lipids are introduced to the bilayer.

Principal Investigator: Professor Adrian Rennie
Local Contact: Dr Nina-Juliane Steinke
Experimenter: Dr Katherine Thompson
Experimenter: Mr Emil Gustafsson
Experimenter: Dr Tim Bowden

DOI: 10.5286/ISIS.E.RB1810580

ISIS Experiment Number: RB1810580

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Adrian Rennie et al; (2018): Structure of oxidised phospholipid bilayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810580

Data is released under the CC-BY-4.0 license.