ISIS Neutron and Muon Source Data Journal

Understanding the molecular origin of cononsolvency

Abstract: The term cononsolvency has been used to describe a situation in which a polymer is less soluble in a mixture of two cosolvents than it is in either one of the pure solvents. If we move into the field of protein stability, then it becomes a desirable feature the fact that the protein become “collapsed” or, better said, folded in a certain solvent mixture. Cononsolvency is thus closely related to the suppression of protein denaturation by stabilizing osmolytes. Cononsolvency behaviour has been found even for small amphiphilic molecules dissolved in methanol/water mixtures. Using a combination of Raman-MCR spectroscopy and MD simulations, it was shown that TBA aggregation is more pronounced in the mixtures than in either of the pure solvents. A thorough structural investigation of TBA solutions is proposed to help the interpretation of thermodynamic and spectroscopic data.

Principal Investigator: Dr Silvia Imberti

DOI: 10.5286/ISIS.E.RB1800065

ISIS Experiment Number: RB1800065

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Silvia Imberti; (2018): Understanding the molecular origin of cononsolvency, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1800065

Data is released under the CC-BY-4.0 license.