ISIS Neutron and Muon Source Data Journal

COMBINED QUASI-ELASTIC NEUTRON SCATTERING AND SR-INFRARED MICROSPECTROSCOPY FOR IMPROVING CHEMOTHERAPEUTIC SUCCESS AGAINST OSTEOSARCOMA

Abstract: This is a joint ISIS/DLS proposal – Quasi-elastic neutron scattering (QENS) and SR-Infrared microspectroscopy (SR-IRMS) are coupled to probe the impact of a Pd(II) anticancer agent on human osteosarcoma, which is the most common primary bone tumour in children and teenagers, with a low success available treatment. This study aims at attaining a thorough understanding of the cytotoxic profile of unconventional cisplatin-like drugs, at a molecular level, from the effect on cellular metabolism to the influence on intracellular water (that can affect vital biochemical processes within the cell and therefore be regarded as a secondary drug target). This is an innovative way of tackling the drug´s pharmacodynamics, aiming at an improved chemotherapeutic activity. The proposed study builds on several successful experiments previously performed for this type of systems at both ISIS and DLS.

Principal Investigator: Dr Maria Paula Marques
Experimenter: Dr Victoria Garcia Sakai
Experimenter: Dr Ana Batista de Carvalho
Experimenter: Mr James Doherty
Experimenter: Dr Gianfelice Cinque
Experimenter: Professor Luis Alberto Batista de Carvalho
Experimenter: Dr Peter Gardner

DOI: 10.5286/ISIS.E.RB1810012

ISIS Experiment Number: RB1810012

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maria Paula Marques et al; (2018): COMBINED QUASI-ELASTIC NEUTRON SCATTERING AND SR-INFRARED MICROSPECTROSCOPY FOR IMPROVING CHEMOTHERAPEUTIC SUCCESS AGAINST OSTEOSARCOMA, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810012

Data is released under the CC-BY-4.0 license.