ISIS Neutron and Muon Source Data Journal

Investigation of PVC plasticizers on phospholipid monolayers

Abstract: Plastic bags are used as containers for storage of donated blood. These bags are typically made out of PVC plasticized with dialkylphthalates (e.g. DEHP), which migrates into the blood and has been found to stabilize the membranes of red blood cells and thereby increases the shelf life of the stored blood. DEHP is inherently toxic and a non-toxic alternative is desired that does not sacrifice shelf life of stored blood. Using neutron reflectometry we aim to establish how different plasticizers interact with phospholipid monolayers and thereby connect biological functions to chemical effects. Insight into the stabilization will lead to greater understanding of how to stabilize blood cells and increase the storage time of collected blood..

Principal Investigator: Dr Tim Bowden
Experimenter: Miss Shirin Nouhi
Experimenter: Professor Adrian Rennie
Local Contact: Dr Arwel Hughes
Experimenter: Mr Emil Gustafsson
Experimenter: Dr Katherine Thompson

DOI: 10.5286/ISIS.E.RB1810574

ISIS Experiment Number: RB1810574

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Tim Bowden et al; (2018): Investigation of PVC plasticizers on phospholipid monolayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810574

Data is released under the CC-BY-4.0 license.