ISIS Neutron and Muon Source Data Journal

Interactions of polyfluorinated substances with a phospholipid bilayer

Abstract: Poly- and perfluoroalkyl substances (PFASs) have been used in various industrial applications and consumer products, but have received increasing global concern due to their persistence, bioaccumulation and adverse effects on living organisms. Some of these compounds are now banned and more are expected to follow. There is, however, a lack of fundamental understanding of their interactions with cell membranes or the dangerous concentration limits. We have studied the interaction of three groups of perfluoroalkyl substances (i.e. carboxylic, sulfonic and sulfonamide acids) with a phospholipid bilayer, DMPC. The results showed that they interact strongly with the lipids and are incorporated into the bilayers, displacing the lipids. The new experiment aims to explore how polyfluorinated substances, which are used as alternatives to perfluoroalkyl substances, interact with DMPC.

Principal Investigator: Dr Maja Hellsing
Experimenter: Professor Lutz Ahrens
Experimenter: Mr Hugo de Campos Pereira
Local Contact: Dr Jos Cooper
Experimenter: Professor Adrian Rennie
Experimenter: Miss Shirin Nouhi
Experimenter: Mr Emil Gustafsson

DOI: 10.5286/ISIS.E.RB1810386

ISIS Experiment Number: RB1810386

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Maja Hellsing et al; (2018): Interactions of polyfluorinated substances with a phospholipid bilayer, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810386

Data is released under the CC-BY-4.0 license.