ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
A SANS Study of Hierarchical Order in DNA Complexes with Trojan Peptides
Abstract: We will use SANS to investigate the nanoscopic structure – i.e., sizes in the range 2-200 nm – of complexes formed by cell-penetrating peptides and nucleic acid species. The hierarchical structure spans a wide range of lengthscales and a wide q range is required. Contrast variation in H2O/D2O will be performed to isolate scattering from the peptide and nucleic acid components in the complexes between so-called Trojan peptides and plasmid DNA. The Trojan peptides to be employed include the Tat-HIV segment GRKKRRQRRRPPQ and Penetratin sequence RQIKIWFQNRRMKWKK.
Principal Investigator: Professor Ian Hamley
Experimenter: Dr Valeria Castelletto
Local Contact: Dr James Doutch
Experimenter: Dr Emerson SILVA
Experimenter: Miss Juliane Pelin
DOI: 10.5286/ISIS.E.RB1810004
ISIS Experiment Number: RB1810004
| Part DOI | Instrument | Public release date | Download Link |
|---|---|---|---|
| 10.5286/ISIS.E.90682630 | LOQ | 13 July 2021 | Download |
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
Select the data format above to find
out more about it.
Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Ian Hamley et al; (2018): A SANS Study of Hierarchical Order in DNA Complexes with Trojan Peptides, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810004
Data is released under the CC-BY-4.0 license.
