ISIS Neutron and Muon Source Data Journal

Hydration of Guanosine, G-quartets and G-quadruplex

Abstract: Guanosine (GMP) is the ideal brick for controlled self-assembly of biocompatible materials, as it has the special ability to self-associate in water to form G-quartets (G4), and four stranded structures, termed G-quadruplexes (G4n). The details of its interaction with the solvent are unknown. For this reason we propose to study on NIMROD the hydration of GMP as a function of concentration in pure water and in KCl-water solutions. The experiment in water will be performed at two solute concentrations, in order to study the hydration of GMP monomers, at the lowest concentration, and to monitor the formation of quartets and their hydration at the highest. A third experiment will be perform after addition of KCl to the solution, in order to stabilize the G-quadruplexes and investigate their hydration. This data will complement previous SAXS results on the same sample.

Principal Investigator: Professor Maria Antonietta Ricci
Experimenter: Professor Fabio Bruni
Local Contact: Dr Silvia Imberti
Experimenter: Dr Mariani
Experimenter: Dr Camilla Di Mino
Experimenter: Dr Michael Di Gioacchino

DOI: 10.5286/ISIS.E.RB1810131

ISIS Experiment Number: RB1810131

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Maria Antonietta Ricci et al; (2018): Hydration of Guanosine, G-quartets and G-quadruplex, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810131

Data is released under the CC-BY-4.0 license.