ISIS Neutron and Muon Source Data Journal

Ibuprofen containing surfactant monolayers: location and stiochiometry of ibuprofen

Abstract: An increasing number of potential drug molecules are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a means of increasing the apparent aqueous solubility of a drug and ensuring exploitation as a medicine. However, little is known about the relationship between drug structure and solubilisation in a micelle. This study focusses on the distribution of the hydrophobic drug, ibuprofen, in surfactant monolayers. Specifically we aim to determine the stiochiommetry and the nature of incorporation of ibuprofen into monolayers formed by 5 different surfactants using neutron reflectivity in combination with contrast variation. Significantly the use of deuterated ibuprofen will allow resolution of its stiochiometry and location in the surfactant monlayer much more accurately than previous studies on related systems.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Dr Dave Barlow
Local Contact: Dr Rebecca Welbourn
Experimenter: Dr Richard Campbell
Experimenter: Miss yanan shao
Experimenter: Dr Peixun Li
Experimenter: Mr Xing Chen

DOI: 10.5286/ISIS.E.RB1720387

ISIS Experiment Number: RB1720387

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2017): Ibuprofen containing surfactant monolayers: location and stiochiometry of ibuprofen , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720387

Data is released under the CC-BY-4.0 license.