ISIS Neutron and Muon Source Data Journal

Antimicrobial peptide-loaded nanogels and their interaction with lipid bilayers

Abstract: Due to increasing antibiotic resistance, bacteria membrane disrupting antimicrobial peptides (AMPs) are of increasing interest as alternatives to classical antibiotics. AMPs are easily degraded in the chemical and enzymatic environment in the body, requiring a protecting drug delivery system (DDS) to ensure effect after administration. Nanogels, designed to be biocompatible, provide a water-rich environment where the AMP can maintain its function. Preliminary work has shown that that combining the AMP with a nanogel improves the membrane disruption. We propose to study a nanogel-AMP formulation and it's interaction with a bacteria model lipid bilayer to elucidate the mechanism of action for this system. This data will be key to understanding the observed synergistic effect between nanogel and AMP that has to date proved impossible using our lab based techniques.

Principal Investigator: Professor Martin Malmsten
Experimenter: Dr Elisa Maria Parra Ortiz
Experimenter: Dr Sara Malekkhaiat Häffner
Experimenter: Dr Kathryn Browning
Local Contact: Dr Jos Cooper
Experimenter: Miss Randi Nordström

DOI: 10.5286/ISIS.E.RB1720043

ISIS Experiment Number: RB1720043

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Martin Malmsten et al; (2017): Antimicrobial peptide-loaded nanogels and their interaction with lipid bilayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720043

Data is released under the CC-BY-4.0 license.