ISIS Neutron and Muon Source Data Journal

Optimizing micellar drug solubilisation using surfactant designed with a hydrophobe matched to that of the drug

Abstract: In our recent research at King’s we have shown that significant increases in micellar drug solubilization can be achieved by ‘matching' the hydrophobe of a drug with the hydrophobe of the surfactant. We have shown proof-of-principle by means of solubilization studies carried out for ibuprofen and indomethacin using the surfactant Triton-X-100 - which has a hydrophobe similar to ibuprofen and dissimilar to that of indomethacin. We subsequently hypothesized that sodium 4-isobutylbenzene sulfonate - which has a hydrophobe even more closely matched to that of ibuprofen - would exhibit even better drug solubilzation, and showed that this was indeed the case.SANS studies of these systems are proposed to determine the structure of the micellar aggregates of sodium 4-isobutylbenzene sulfonate (4IBS) and the structure of these micelles with incorporated ibuprofen and indomethacin.

Principal Investigator: Professor Jayne Lawrence
Experimenter: Dr Dave Barlow
Local Contact: Dr Najet Mahmoudi
Experimenter: Mr Xing Chen
Experimenter: Miss yanan shao
Experimenter: Dr Delaram Ahmadi

DOI: 10.5286/ISIS.E.RB1810548

ISIS Experiment Number: RB1810548

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2018): Optimizing micellar drug solubilisation using surfactant designed with a hydrophobe matched to that of the drug, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810548

Data is released under the CC-BY-4.0 license.