ISIS Neutron and Muon Source Data Journal

Determination of the absorbed amount and location of a hydrophobic drug in surfactant monolayers

Abstract: Many drugs are both poorly water-soluble (hydrophobic) and lipophilic in nature and are therefore incorporated into surfactant micelles and monolayers. As the incorporation of drug into surfactant monolayers is expected to mirror its distribution in surfactant micelles, the study of drug distribution into surfactant monolayers should provide useful information about the nature and extent of drug solubilisation. However, to date very little work has been undertaken to determine the amount of drug incorporated and the extent of its penetration into surfactant monolayers. The present study will determine the amount and distribution of the testosterone enanthate into monolayers formed by a range of C12 surfactants of varying head group at the air/water surface. The study will provide invaluable information in understanding the preferred location of drug in surfactant micelles.

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Rebecca Welbourn
Experimenter: Mr Xing Chen
Experimenter: Miss yanan shao
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Dave Barlow

DOI: 10.5286/ISIS.E.RB1710355

ISIS Experiment Number: RB1710355

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2017): Determination of the absorbed amount and location of a hydrophobic drug in surfactant monolayers , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710355

Data is released under the CC-BY-4.0 license.