ISIS Neutron and Muon Source Data Journal

Steroidal drug containing dodecyl sulphate monolayers: effect of counterion

Abstract: An number of potential drugs, including steroidal drugs are extremely water insoluble, limiting their commercialisation as medicines. Solubilisation of drug in surfactant micelles is a means of increasing the apparent aqueous solubility of a drug and ensuring exploitation as a medicine. Micelles formed by the anionic surfactant, sodium dodecyl sulphate, have been shown to be an excellent solubiliser of steroidal drug. Changing the counterion has been shown to influence solubilisation in a micelle with lithium increasing solubilisation and ammonium decreasing solubilisation. We aim to determine the effect of the counterion ion on the stiochiommetry and the nature of incorporation of steroidal drug into monolayers formed by different dodecyl sulphate surfactants, namely those containing either Li or NH4 counterion, using neutron reflectivity in combination with contrast variation.

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Peixun Li
Experimenter: Mr Xing Chen
Experimenter: Miss yanan shao
Experimenter: Dr Dave Barlow

DOI: 10.5286/ISIS.E.RB1720384

ISIS Experiment Number: RB1720384

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2017): Steroidal drug containing dodecyl sulphate monolayers: effect of counterion , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720384

Data is released under the CC-BY-4.0 license.