ISIS Neutron and Muon Source Data Journal

SANS study of the effects of leucine-isoleucine sequences on the self-assembly of amphiphilic short peptides

Abstract: In this work, we have selected a group of short peptides containing 4-5 Ile (I) and 1 Lys (K) and examined the effects of sequential substitution of one I by L on nanostructuring. Through extensive studies by AFM and TEM, we found that sequential replacements can hugely affect nanostructures via altering peptide packing, layer thickness and twisting. This is because L disfavors hydrogen bonding whilst I encourages it. These structural effects affect how molecules can align and form layers and extend to higher orders of structures. Because these sizes are in the order of a few nanometers and difficult to image but are ideal for SANS measurements. SANS2d is preferred because of its high structural sensitivity and wider Q range to cover weak signals and different size ranges. We request 3 days of SANS2d to undertake the tasks planned.

Principal Investigator: Professor Jian Lu
Experimenter: Dr Xuzhi Hu
Experimenter: Professor Hai Xu
Local Contact: Dr Steve King
Experimenter: Mr Zhiming Lu
Experimenter: Dr Zongyi Li
Experimenter: Professor Jiqian Wang
Experimenter: Mr Huayang Liu

DOI: 10.5286/ISIS.E.RB1810428

ISIS Experiment Number: RB1810428

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jian Lu et al; (2018): SANS study of the effects of leucine-isoleucine sequences on the self-assembly of amphiphilic short peptides, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810428

Data is released under the CC-BY-4.0 license.