ISIS Neutron and Muon Source Data Journal

Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions: small-angle neutron scattering measurements

Abstract: The current project aims to 1) elucidate how bile salts (BS) structure influences their interfacial behaviour and role during lipolysis; 2) to study the potential ability of specific food emulsifiers to inhibit BS adsorption, and thus lipase adsorption, at the lipid/water interface. Small-angle neutron scattering beam time is requested here to investigate BS self-assembly in the bulk and to characterise the structure of emulsion droplet interfaces stabilised by food emulsifiers, after interaction with BS and lipase/co-lipase. Two structurally different BS showing contrasting interfacial behaviours have been selected in this work. Three methylcelluloses are chosen as emulsifiers due to their demonstrated cholesterol-lowering capacity. BS adsorption at droplets interfaces will be studied and equilibrium structures after interaction with lipase measured, as a function of BS type and amount.

Principal Investigator: Dr Cecile Dreiss
Experimenter: Miss Suzette Lust
Experimenter: Ms Tong Yu
Experimenter: Professor Peter Wilde
Experimenter: Dr Isabelle Grillo
Experimenter: Dr Olivia Pabois
Experimenter: Dr Richard Harvey
Local Contact: Dr Najet Mahmoudi

DOI: 10.5286/ISIS.E.RB1720349

ISIS Experiment Number: RB1720349

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Cecile Dreiss et al; (2018): Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions: small-angle neutron scattering measurements, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720349

Data is released under the CC-BY-4.0 license.