ISIS Neutron and Muon Source Data Journal

The Effect of Sorbate-Framework Interactions on Controlled Drug Release by Zeolites

Abstract: To understand the controlled release of drug molecules from zeolite hosts, we propose to study using INS the interactions of beta-blocker atenolol with the Brønsted acid sites in potential zeolite candidates for its controlled release, H-FAU (Si/Al=5), H-FAU(Si/Al=80) and zeolite beta. The H-FAU (5) sample releases the drug over a 24 hour period, whereas the H-FAU (80) sample releases over 10 days. This is counterintuitive as the much larger number of Brønsted acid sites in H-FAU (5) should slow the molecular mobility through interactions with the sorbate. QENS experiments (RB1710135) suggest that the fundamental freedom of mobility is indeed higher in the H-FAU (5) sample, and diffraction data suggests more lattice distortion upon drug adsorption in the slower releasing H-FAU (80) sample. We aim to rationalise these observations through probing sorbate-Brønsted site interactions.

Principal Investigator: Dr Alexander O'Malley
Local Contact: Dr Jeff Armstrong
Experimenter: Dr Paul Cox
Experimenter: Mr Anthony Wise

DOI: 10.5286/ISIS.E.RB1810081

ISIS Experiment Number: RB1810081

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Alexander O'Malley et al; (2018): The Effect of Sorbate-Framework Interactions on Controlled Drug Release by Zeolites, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810081

Data is released under the CC-BY-4.0 license.