ISIS Neutron and Muon Source Data Journal

The effect of bilayer rigidity on the interactions with perfluoroalkyl compounds

Abstract: Perfluoroalkyl substances (PFASs) are used extensively in industrial products although have been identified as emerging pollutants accumulating in wildlife and environment. PFASs exhibit different uptake behavior in plants compared to worms and since it has been established that they aggregate in lipid-rich tissues, it is important to investigate the dependence of their interactions with different types of lipid that form cell membranes. As the first part of this project, we have studied the interaction of a wide range of perfluoroalkyl substances with saturated phospholipid, DMPC, as a simple model system for biological interfaces. The new experiment aims to study the interaction of PFASs with an unsaturated lipid, DOPC, which forms a softer bilayer and understand to what extent the rigidity and ordering of the bilayer can affect the interactions and incorporation of PFASs.

Principal Investigator: Professor Lutz Ahrens
Local Contact: Dr Arwel Hughes
Experimenter: Mr Emil Gustafsson
Experimenter: Professor Adrian Rennie
Experimenter: Miss Shirin Nouhi
Experimenter: Mr Hugo de Campos Pereira
Local Contact: Dr Mario Campana
Experimenter: Dr Maja Hellsing

DOI: 10.5286/ISIS.E.RB1810491

ISIS Experiment Number: RB1810491

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Lutz Ahrens et al; (2018): The effect of bilayer rigidity on the interactions with perfluoroalkyl compounds, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810491

Data is released under the CC-BY-4.0 license.