ISIS Neutron and Muon Source Data Journal

Investigation on the air-water adsorption behaviour of N-acyl amino acid surfactants

Abstract: N-acyl amino acids are promising anionic amphiphilic molecules with an improved toxicological profile in comparison to the most common used sulfate-based surfactants. Previous reflectivity measurements have evidenced some differences in the interaction of N-decanoyl surfactants with the bilayer as a function of the different polar head. We observed for C10LEU the insertion of surfactant into the lipid bilayer at concentrations below CMC and a complete lipid removal at concentration double of CMC. On the contrary, C10ALA and C10SER maintained the bilayer integrity up to a concentration of three times CMC. We propose here to determine by reflectivity measurements the adsorption at the air-water interface of these compounds. This information is essential for a full understanding of the different behaviour of the analysed N-decanoyl amino acid as regards cytotoxicity and membrane interaction

Principal Investigator: Dr Mario Campana
Experimenter: Dr Diego Romano Perinelli
Experimenter: Professor Luca Casettari

DOI: 10.5286/ISIS.E.RB1720311

ISIS Experiment Number: RB1720311

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Mario Campana et al; (2018): Investigation on the air-water adsorption behaviour of N-acyl amino acid surfactants, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720311

Data is released under the CC-BY-4.0 license.