ISIS Neutron and Muon Source Data Journal

Interactions of Surfactant Mixtures with Phospholipid Vesicles: the Influence of Hydrophobic Chain Fluidity

Abstract: Surfactants have been widely used in cosmetics, detergents and pharmaceutical industries. These applications are always accompanied by surfactant-induced skin irritation which is linked to surfactant interaction with the components of the outermost layer of skin: dead corneocytes and extracellular lamellar lipid. Therefore, for surfactant-induced skin irritation, the interaction of skin lipid with surfactants should be studied. In this proposal, phospholipid vesicles are been used as a first step to model the lipid in skin. SANS will be employed to study the interaction of phospholipid vesicle with cationic/anionic surfactant mixtures. We try to reveal how the surfactant mixture incorporate into and disintegrate the phospholipid vesicle and explain the observed efficacy of mixed surfactants.

Principal Investigator: Dr Yao Chen
Experimenter: Dr John Webster
Experimenter: Dr Peixun Li
Local Contact: Dr Robert Dalgliesh
Experimenter: Mr KE FA

DOI: 10.5286/ISIS.E.RB1810816

ISIS Experiment Number: RB1810816

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Yao Chen et al; (2018): Interactions of Surfactant Mixtures with Phospholipid Vesicles: the Influence of Hydrophobic Chain Fluidity, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1810816

Data is released under the CC-BY-4.0 license.