ISIS Neutron and Muon Source Data Journal

Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions: neutron reflectivity measurements

Abstract: The current project aims at elucidating how bile salts (BS) structure influences their interfacial behaviour and their impact on fat digestion. Neutron reflectivity (NR) is the only technique that can provide a detailed molecular picture of the BS/lipids interface, over time and at equilibrium. We have measured the interactions of two distinct BS, sodium taurocholate and sodium taurodeoxycholate, with a lipid film at the air/water interface, using the Langmuir trough and NR techniques. We will be complementing these studies with NR at the oil/water interface, which reflects the actual fat droplet/water interface. We now propose to use NR at the oil/water interface with two glyco-conjugated BS, sodium glycocholate and sodium glycodeoxycholate, to confirm our assumption that BS interfacial behaviour is mostly linked to the bile acid portion, i.e., the position and number of hydroxyl group.

Principal Investigator: Dr Cecile Dreiss
Experimenter: Dr Ali Zarbakhsh
Experimenter: Dr Yuri Gerelli
Local Contact: Dr Maxmilian Skoda
Experimenter: Dr Richard Harvey
Experimenter: Dr Isabelle Grillo
Experimenter: Dr Olivia Pabois
Experimenter: Professor Peter Wilde
Local Contact: Dr Rebecca Welbourn

DOI: 10.5286/ISIS.E.RB1720440

ISIS Experiment Number: RB1720440

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Cecile Dreiss et al; (2017): Understanding the interfacial behaviour of bile salts to better engineer lipid emulsions: neutron reflectivity measurements, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720440

Data is released under the CC-BY-4.0 license.