ISIS Neutron and Muon Source Data Journal

Understanding the antimicrobial activity of the salivary protein Histatin 5

Abstract: The goal of this project is to understand the antimicrobial activity of the intrinsically disordered salivary protein Histatin 5, which acts in defence against oral candidiasis caused by Candida albicans. From the literature it is still unknown how the peptide transports itself through the membrane, but it is suggested to not be an ordinary pore-opening transport, instead it has been attributed to its metal binding abilities. Studies have established that various transitional metals, such as Zn, Ni, Cu, and Fe, are intrinsically present in the saliva. In this project, we aim to investigate not only how Histatin 5 interacts with the SiO2 surface but also how Histatin 5 interacts with membranes, to be able to detect structural changes of the membrane, as well as determine how Histatin 5 inserts into the membrane. For this purpose, a combined experimental and theoretical approach is used.

Principal Investigator: Professor Marie Skepö
Experimenter: Dr Sandeep Chakane
Experimenter: Miss Stéphanie Jephthah
Experimenter: Miss Carolina Cragnell
Experimenter: Dr Yuri Gerelli
Local Contact: Dr Rebecca Welbourn

DOI: 10.5286/ISIS.E.RB1800006

ISIS Experiment Number: RB1800006

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Marie Skepö et al; (2018): Understanding the antimicrobial activity of the salivary protein Histatin 5, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1800006

Data is released under the CC-BY-4.0 license.