ISIS Neutron and Muon Source Data Journal

Determining the Structure of Simple Stratum Corneum Lipid Models for Drug Delivery Studies

Abstract: Using a simple model we wish to mimic the lipid structure of the stratum corneum (the top layer of the skin). The simple model offers several advantages to our research area including: enabling more concentrated investigations between the interactions of particular lipid classes; reducing the number of lipids (not all of which are easily obtainable); simplifying the preparation of the models that would result reduced inconsistences between samples; as well as more detailed interpretation of the lipid organization than what is available for the more complex model.We will gain the information on the arrangement of the lipids with the use of specific deuterated lipids. In this experiment we wish to deuterated cholesterol and the free fatty acids individually, two components that are essential in the stratum corneum lipid matrix.

Principal Investigator: Dr Joke Bouwstra
Experimenter: Mrs Lorretta Uche
Local Contact: Dr Robert Dalgliesh
Experimenter: Mr gerrit gooris
Experimenter: Dr Charlotte Beddoes

DOI: 10.5286/ISIS.E.RB1869000

ISIS Experiment Number: RB1869000

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Joke Bouwstra et al; (2017): Determining the Structure of Simple Stratum Corneum Lipid Models for Drug Delivery Studies, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1869000

Data is released under the CC-BY-4.0 license.