ISIS Neutron and Muon Source Data Journal

Antimicrobial Mechanisms of Model Biocides via Their Interaction with Lipopolysaccharides Studied by Neutron Reflection

Abstract: The global increase of bacterial resistance to antibiotics has led to increasing interest in research focusing on the development and characterization of new antimicrobial agents. One class of promising antimicrobials found in nature are Antimicrobial Peptides (AMP’s). In contrast to most existing biocides, it is thought that AMPs would share broadly similar modes of membrane disruption. We have designed a novel class of AMPs with the general sequence G(IIKK)nI-NH2, with n = 3-4, denoted as G3 and G4. We propose to compare the binding of these peptides to the spread LPS monolayer with the performance from model biocides SDS, DTAB and trichosan, to identify any structural differences in their membrane attacking processes.

Principal Investigator: Dr Luke Clifton
Experimenter: Mr KE FA
Experimenter: Dr Meiwen Cao
Experimenter: Professor Jian Lu
Experimenter: Mr Haoning Gong
Experimenter: Miss Daniela Ciumac
Local Contact: Dr Arwel Hughes
Local Contact: Dr Mario Campana

DOI: 10.5286/ISIS.E.RB1720227

ISIS Experiment Number: RB1720227

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Luke Clifton et al; (2017): Antimicrobial Mechanisms of Model Biocides via Their Interaction with Lipopolysaccharides Studied by Neutron Reflection, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1720227

Data is released under the CC-BY-4.0 license.