ISIS Neutron and Muon Source Data Journal

Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic lipid bilayers

Abstract: Polymers are commonly used in drug delivery to create dosage forms that enable delivery of the active ingredient to the site of action within the body. Towards controlled drug delivery polymers enable the development of systems that help to minimise side effects. There are a variety of ways in which polymers can interact with cell membranes, via specific receptors and also via disruption of the lipid membrane itself. We have been investigating the role of different properties of polymers on their ability to interact with lipid membranes. PAMAM is a highly branched polymer with either cationic (G5) or anionic (G4.5) end groups. In this proposal we ask for neutron reflectometry INTER beam time to investigate the interfacial structure of lipid layers in the presence of PAMAM G4.5 and G5.

Principal Investigator: Professor Rebecca Green
Local Contact: Dr Arwel Hughes
Experimenter: Dr Luke Clifton
Experimenter: Ms Marleen Wilde
Experimenter: Dr Francesca Greco
Experimenter: Mr Christopher Wilde
Experimenter: Dr Elena Kabova

DOI: 10.5286/ISIS.E.RB1710336

ISIS Experiment Number: RB1710336

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Rebecca Green et al; (2017): Binding behaviour of PAMAMs G5 and G4.5 to zwitterionic and anionic lipid bilayers, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1710336

Data is released under the CC-BY-4.0 license.