ISIS Neutron and Muon Source Data Journal

Self-assembling antimicrobial peptides: interactions with model lipid membranes

Abstract: We propose to investigate antimicrobial peptides that self-assemble into well-defined nanostructures. Previous SAXS results have shown that the peptides form rather robust platelets/fibers (“nanosheets”) with well-defined dimension of about 100x6x3 nm3 which persist with the attachment of poly(ethylene glycol) (“PEGylation”). Recent investigations have shown that the peptides that form nanosheets exhibit low cytotoxicity but significant antimicrobial action, while unstructured peptides were significantly more toxic and also prone to enzymatic degradation. In order to understand the biological behaviour, the basic physico-chemical characterizations are needed, in particular at surfaces that might provide insight to their cell interactions.

Principal Investigator: Professor Reidar Lund
Experimenter: Mr Nico Koenig
Experimenter: Miss Josefine Eilsø Nielsen
Local Contact: Dr Maxmilian Skoda
Experimenter: Professor Marité Cárdenas Gómez

DOI: 10.5286/ISIS.E.RB1910440

ISIS Experiment Number: RB1910440

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Reidar Lund et al; (2019): Self-assembling antimicrobial peptides: interactions with model lipid membranes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910440

Data is released under the CC-BY-4.0 license.