ISIS Neutron and Muon Source Data Journal

Investigating structural organization of hyaluronic acid-based nanogels encapsulating antimicrobial drugs

Abstract: We want to characterize the physico-chemical properties of self-assembling nanogels composed of octenyl-succinic anhydride modified hyaluronic acid and lipophilic antibiotics or antimicrobial peptides. We have assessed the efficacy of antimicrobial drugs in OSA-HA nanogels in vitro and in vivo, but we still lack basic understanding of the structure of nanogels upon drug loading and the effect of this structure on the formulation efficacy. We want to assess the structural organization of the nanogels over time, the spatial distribution of the drug within the gel and the release mechanism from the gel. Additionally, we would like to look into the behaviour of nanogels in blood plasma and structural stability after freeze drying and reconsitution. By obtaining such insight on structural organization, we will be able to better interpret results of efficacy studies and optimize the nanogels.

Principal Investigator: Professor Hanne Mørck Nielsen
Experimenter: Dr Kathryn Browning
Local Contact: Dr Sarah Rogers
Experimenter: Dr Sylvia Klodzinska

DOI: 10.5286/ISIS.E.RB1910284

ISIS Experiment Number: RB1910284

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Hanne Mørck Nielsen et al; (2019): Investigating structural organization of hyaluronic acid-based nanogels encapsulating antimicrobial drugs, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910284

Data is released under the CC-BY-4.0 license.