ISIS Neutron and Muon Source Data Journal

Correlating the Internal Structure of Drug-Loaded Polymeric Nanoparticles to Drug Release

Abstract: The understanding the drug release mechanism from polymeric nanoparticles (PNPs) requires a detailed characterisation of the PNPs internal structure. Small-angle neutron scattering in combination with contrast variation is a unique probe that can provide not only quantitative analysis of core size and shell thicknesses, but also yield the chemical composition of the drug-loaded core. Here we propose a series of experiments to fully characterise the core of our PNPs. This work will also give an insight into any changes to the PNPs polyethylene glycol “stealth layer” which can be tailored to affect the PNPs biodistribution and circulation lifetime, thereby controlling the amount of drug delivered to the patient.

Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Najet Mahmoudi
Experimenter: Mr Weimin Li
Local Contact: Dr Sarah Rogers
Experimenter: Dr Mark Jackman
Experimenter: Dr Kevin Treacher
Experimenter: Dr Manikandan Kadirvel
Experimenter: Dr Alice Spadea
Experimenter: Miss Yixuan Yan
Experimenter: Dr Yu Lu

DOI: 10.5286/ISIS.E.RB1910321

ISIS Experiment Number: RB1910321

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Jayne Lawrence et al; (2019): Correlating the Internal Structure of Drug-Loaded Polymeric Nanoparticles to Drug Release , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1910321

Data is released under the CC-BY-4.0 license.