ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Assessing the protein conformation and surface activity in protein-based nanohybrids at the air/water interface
Abstract: We aim to study the structure of interfacial layers formed thanks to the interaction between negatively charged silica nanoparticles (NPs) and bovine serum albumin (BSA). In particular, we will investigate how the dispersion composition (NP/BSA ratio and ionic strength) will affect the layer structure and density by means of neutron reflectometry (NR). Then, the monolayers will undergo a compression/expansion cycle in a Langmuir trough and, during both compression and expansion, NR will be performed. This will allow determining structural modifications of the layer upon mechanical deformation and associated eventual desorption/re-adsorption phenomena. This study will provide new fundamental insight to characterize and control the protein conformation at liquid interfaces. Moreover, it will allow assessing the use of mixed NP/BSA dispersions as novel green adaptive surfactants for stabilizing complex fluid interfaces.
Public release date: 19 March 2028
Principal Investigator: Professor Giovanni Calogero Li Destri Nicosia
Experimenter: Professor Irene Russo Krauss
Local Contact: Dr Mario Campana
Experimenter: Mrs Laura Di Rienzo
Experimenter: Dr Roberta Ruffino
Experimenter: Mr Pascal Tomasella
DOI: 10.5286/ISIS.E.RB2410233-2
Parent DOI: 10.5286/ISIS.E.RB2410233
ISIS Experiment Number: RB2410233
Part Number: 2
This dataset is NOT yet publicly available.
The release date is: 19 March 2028
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Date of Experiment: 15 March 2025
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Giovanni Calogero Li Destri Nicosia et al; (2025): Assessing the protein conformation and surface activity in protein-based nanohybrids at the air/water interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2410233-2
Data is released under the CC-BY-4.0 license.
