ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
The antifungal activity of GIK-modified amphiphilic peptides
Abstract: The fungal infection has emerged as a significant global health concern primarily due to the misuse of drugs resulting from multidrug resistance and the slow pace of developing new antifungal agents. However, antifungal peptides (AFPs) may be a competitive candidate for solving this dilemma. AFPs function by binding to fungal membranes via surface electrostatic potentials, subsequently inducing membrane depolarization and increased permeability through hydrophobic interactions. This mechanism acts swiftly, effectively eliminating pathogens before resistance mechanisms can develop. Compared to natural AFPs, synthetic AFPs display enhanced properties including low toxicity to host cells, fewer unknown side effects, sufficient efficacy, stability, simpler sequences and low production costs and GIK with the sequence G(IIKK)3I-NH2 is spurious among them as an antifungal agent. Modifying GIK by altering the amino acids sequence to manipulate its electoral and hydrophobic properties may refine this amphophilic peptide's antifungal.
Public release date: 18 February 2028
Principal Investigator: Professor Jian Lu
Experimenter: Miss Tianhao Ge
Experimenter: Mr Shilin Deng
Local Contact: Dr Stephen Hall
Experimenter: Mr kangcheng shen
Experimenter: Dr Mingrui Liao
Local Contact: Dr Mario Campana
Experimenter: Miss Yingyu Wang
DOI: 10.5286/ISIS.E.RB2420402-1
Parent DOI: 10.5286/ISIS.E.RB2420402
ISIS Experiment Number: RB2420402
Part Number: 1
This dataset is NOT yet publicly available.
The release date is: 18 February 2028
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Date of Experiment: 16 December 2024
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jian Lu et al; (2024): The antifungal activity of GIK-modified amphiphilic peptides, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2420402-1
Data is released under the CC-BY-4.0 license.
