ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Does oxidative damage to mammalian membranes make them susceptible to antimicrobial peptides?
Abstract: The antibacterial peptide protegrin inserts preferentially into bacterial model membranes, which are negatively charged, compared to mammalian model membranes which carry no net charge. Oxidation of lipid membranes is now known to change their interaction with peptides, often considerably. In this proposal we wish to determine if oxidation of model mammalian membranes, leading to carboxylic acid groups in the lipid tail which will i) be predominantly deprotonated at pH 7.4, and ii) subsequently reorientate so that the carboxylate group can interact with the lipid head region, leads to increased interaction with the antibacterial peptide protegrin.
Public release date: 18 February 2028
Principal Investigator: Professor Katherine Thompson
Experimenter: Professor Adrian Rennie
Local Contact: Dr Maxmilian Skoda
Experimenter: Miss Sophie Burr
DOI: 10.5286/ISIS.E.RB2220534-1
Parent DOI: 10.5286/ISIS.E.RB2220534
ISIS Experiment Number: RB2220534
Part Number: 1
This dataset is NOT yet publicly available.
The release date is: 18 February 2028
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Date of Experiment: 17 December 2024
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Katherine Thompson et al; (2024): Does oxidative damage to mammalian membranes make them susceptible to antimicrobial peptides?, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220534-1
Data is released under the CC-BY-4.0 license.
