ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Interaction of mucin and stimuli-responsive gels at interfaces
Abstract: Intranasal drug delivery offers a promising alternative with advantages like improved patient compliance, enhanced bioavailability, and reduced systemic side effects. However, a key challenge lies in finding materials with strong mucoadhesive properties to overcome mucociliary clearance, a defense mechanism in the respiratory system. Establishing robust interactions between drug carriers and mucin, facilitated by mechanisms like electrostatic attractions, van der Waals forces, hydrophobic interactions, hydrogen bonding, and chain entanglement, is crucial. Our proposal focuses on assessing stimuli-responsive gels and their interplay with the mucin layer using neutron reflectometry, enabling a comprehensive exploration of these interactions.
Public release date: 18 July 2027
Principal Investigator: Dr Ali Zarbakhsh
Experimenter: Mr Davide Mazzali
Local Contact: Dr Mario Campana
Experimenter: Miss Gabriela Rath
DOI: 10.5286/ISIS.E.RB2410166-2
Parent DOI: 10.5286/ISIS.E.RB2410166
ISIS Experiment Number: RB2410166
Part Number: 2
This dataset is NOT yet publicly available.
The release date is: 18 July 2027
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Date of Experiment: 15 July 2024
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Dr Ali Zarbakhsh et al; (2024): Interaction of mucin and stimuli-responsive gels at interfaces, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2410166-2
Data is released under the CC-BY-4.0 license.
