ISIS Neutron and Muon Source Data Journal

This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.

ISIS Neutron and Muon Source

ISIS Neutron and Muon Data

Neutron Reflection Studies for the Strong Insertion of Sphingosine in Lipid Membrane at the Solid/Liquid Interface

Data collected on the
INTER instrument
at the ISIS facility

Abstract: Sphingosine, an important component of the sphingolipids, serves as the backbone of the sphingolipids, and works as the signal molecule to regulate cell fate. The incursion of sphingosine into membranes is always accompanied by an increase of membrane permeability, which results in the leakage from the cytosol, and eventually the cell death. The reason why the sphingosine increases the membrane permeability is currently unclear, but structural changes in the membrane after incorporating sphingosine must play an important role. We propose to use neutron reflectivity (NR) combining with deuterium labelling technique to investigate the planar lipid membrane structure at the solid/water interface in the presence of sphingosine with two various hydrophobic chains. This study will provide the basic understanding of the interfacial behaviour of sphingosine and will give constructive support to elucidate how the unique structure of sphingosine affect the membrane.

Public release date: 25 July 2027

Principal Investigator: Dr Peixun Li
Experimenter: Dr Zi Wang
Experimenter: Professor Jeffery Penfold
Experimenter: Dr John Webster
Experimenter: Dr Kun Ma
Experimenter: Dr Yao Chen
Experimenter: Dr Luke Clifton
Local Contact: Dr Maxmilian Skoda
Experimenter: Mr Yonghang Mu

DOI: 10.5286/ISIS.E.RB2310666-1

Parent DOI: 10.5286/ISIS.E.RB2310666

ISIS Experiment Number: RB2310666

Part Number: 1

This dataset is NOT yet publicly available.
The release date is: 25 July 2027

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the dataset

Date of Experiment: 20 July 2024

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Peixun Li et al; (2024): Neutron Reflection Studies for the Strong Insertion of Sphingosine in Lipid Membrane at the Solid/Liquid Interface, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2310666-1

Data is released under the CC-BY-4.0 license.