ISIS Neutron and Muon Source Data Journal

Effect of Liposome Surface Charge and Rigidity on Interaction with Gold Nanoparticles

Abstract: Liposomes and cell membranes have in common the outer double lipid membrane, and their compositions usually includes phosphatidylcholine lipids. Therefore, liposomes can be used as a proxy to study cell membrane stability and interactions with nanomaterials. To investigate liposome/AuNP interaction, liposomes of different phosphocholine composition and phase with zwitterionic, negative and positive surface charges in liquid and gel state are fabricated and blended with monodisperse gold nanoparticles (AuNP). The resulting systems are then characterized by a combination of techniques, namely, DLS, ELS, UV-Vis, SAXS, and TEM. Our Results show significant differences in liposome/nanoparticle interactions between the samples under study. This leads to different strength of interaction and levels of AuNP aggregation, depending on the membrane rigidity as well as sign and strength of the liposome surface charge.

Public release date: 30 September 2026

Local Contact: Dr Najet Mahmoudi
Experimenter: Miss Ghazaleh Mazaheri Tehrani
Experimenter: Dr Constantina Sofroniou
Experimenter: Miss Malika Singh

DOI: 10.5286/ISIS.E.RB2300048-1

Parent DOI: 10.5286/ISIS.E.RB2300048

ISIS Experiment Number: RB2300048

Part Number: 1

Date of Experiment: 20 September 2023

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Najet Mahmoudi et al; (2023): Effect of Liposome Surface Charge and Rigidity on Interaction with Gold Nanoparticles, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2300048-1

Data is released under the CC-BY-4.0 license.