ISIS Neutron and Muon Source Data Journal

This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.

ISIS Neutron and Muon Source

ISIS Neutron and Muon Data

Peptide-mediated lipid transport in lung surfactant models: increasing the complexity while lowering the surface tension

Data collected on the
INTER instrument
at the ISIS facility

Abstract: Synthetic therapies to treat infant respiratory distress syndrome are urgently needed, as current treatments have stringent storage conditions and are inaccessible in developing countries. We need to understand better how lung surfactant protein B (SP-B) transports lipid between vital lipid reservoirs (when breathing in) to the surface monolayer keeping surface tension close to zero (when breathing out). This proposal builds on a broader project and results from a neutron reflectometry experiment to increase the complexity of the lung surfactant model at more realistic low surface tension values of relevance to lung function. Novelty in the approach is not only the low surface tension but also the selective deuteration of different components of the lipid mixture to highlight the reservoir composition directly with respect to the presence of a peptide analogue of SP-B for the first time.

Public release date: 24 February 2026

Principal Investigator: Dr Richard Campbell
Experimenter: Dr Yixuan Yan
Local Contact: Dr Rebecca Welbourn
Experimenter: Professor Jayne Lawrence
Experimenter: Ms Marina Efstratiou
Experimenter: Dr Prajna Dhar
Experimenter: Dr Pinchu Xavier
Experimenter: Dr Glenn Coope
Experimenter: Dr Daniel Ondo
Experimenter: Mr Javier Carrascosa Tejedor
Experimenter: Mr Samuel Winnall

DOI: 10.5286/ISIS.E.RB2220387-2

Parent DOI: 10.5286/ISIS.E.RB2220387

ISIS Experiment Number: RB2220387

Part Number: 2

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the dataset

Date of Experiment: 22 February 2023

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
Select the data format above to find out more about it.

Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Dr Richard Campbell et al; (2023): Peptide-mediated lipid transport in lung surfactant models: increasing the complexity while lowering the surface tension, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2220387-2

Data is released under the CC-BY-4.0 license.