ISIS Neutron and Muon Source Data Journal

Determination of the dynamic exchange kinetics of hydrophobically trapped cyclic peptide nanotubes

Abstract: Cyclic peptides with alternating side chain stereochemistry are capable of self-assembling into long nanotubes (CPNTs). The conjugation of polymers to these peptides renders the resulting CPNTs water soluble, whilst providing functionality. CPNTs have promising applications as drug delivery vectors where controlled assembly and disassembly is required for tailoring drug release. In order to control the dynamic behaviour of CPNTs, we have designed and synthesised CPNTs conjugated to block copolymers with a central hydrophobic block to function as a kinetic trap. Here, we propose to use time-resolved SANS combined with isotopic contrast matching to determine the exchange kinetics of kinetically trapped peptides between hydrogenated and deuterated CPNTs. This will enable the design of CPNTs with controlled, tunable dynamics as drug delivery vectors.

Public release date: 20 November 2023

Principal Investigator: Professor Sebastien Perrier
Experimenter: Miss Maria Kariuki
Experimenter: Dr Qiao Song
Local Contact: Dr Robert Dalgliesh
Experimenter: Dr Stephen Hall

DOI: 10.5286/ISIS.E.RB2010379-1

Parent DOI: 10.5286/ISIS.E.RB2010379

ISIS Experiment Number: RB2010379

Part Number: 1

Date of Experiment: 16 November 2020

Publisher: STFC ISIS Neutron and Muon Source

Data format: RAW/Nexus
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Data Citation

The recommended format for citing this dataset in a research publication is as:
[author], [date], [title], [publisher], [doi]

For Example:
Professor Sebastien Perrier et al; (2020): Determination of the dynamic exchange kinetics of hydrophobically trapped cyclic peptide nanotubes, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010379-1

Data is released under the CC-BY-4.0 license.