ISIS Neutron and Muon Source Data Journal
This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
Self-assembly of the beta blocker, propranolol hydrochloride under physiological conditions
Abstract: Some drug molecules are surface active and, as such, self-assemble into micellar structures when present above a concentration known as their critical micelle concentration (cmc), although there is evidence of pre-micellar aggregation with some drugs. What is not currently understood is whether this ?surfactant-like? behaviour is important for the drug's therapeutic activity. As part of a larger study aimed at gaining insight into the structure-function relationship between a drug?s surface active nature and its therapeutic activity, we wish to perform contrast variation SANS experiments in order to understand how the conditions that the drug would encounter in the body might influence its aggregation behaviour. The results of this study will be combined with molecular dynamic studies.
Public release date: 11 December 2023
Principal Investigator: Professor Jayne Lawrence
Local Contact: Dr Najet Mahmoudi
Experimenter: Dr Yixuan Yan
Experimenter: Dr Richard Campbell
Experimenter: Dr Dave Barlow
DOI: 10.5286/ISIS.E.RB2010651-1
Parent DOI: 10.5286/ISIS.E.RB2010651
ISIS Experiment Number: RB2010651
Part Number: 1
Date of Experiment: 05 October 2020
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
The recommended format for citing this dataset in a research
publication is as:
[author], [date], [title], [publisher],
[doi]
For Example:
Professor Jayne Lawrence et al; (2020): Self-assembly of the beta blocker, propranolol hydrochloride under physiological conditions , STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB2010651-1
Data is released under the CC-BY-4.0 license.
