This is a page describing data taken during an experiment at the ISIS Neutron and Muon Source. Information about the ISIS Neutron and Muon Source can be found at https://www.isis.stfc.ac.uk.
API-DES: improving drug solubility with deep eutectic solvents
Abstract: Improving the efficiency of existing drugs is currently one of the major goals of pharmaceutical industries. Rather than developing new drugs, which requires new clinical trials, the strategy is to improve the already tried-and-tested therapies. One of the characteristics with great ceiling for improvement is hydrophilicity; approximately 40% of approved drugs and nearly 90% of drugs under development are poorly water soluble, which leads to low bioavailability. In this sense, deep eutectic solvents comprising active pharmaceutical ingredients (API-DES) have emerged as alternative media capable of solubilizing poorly soluble compounds and enhance their bioavailability. In this proposal, inelastic neutron scattering (INS) will be applied to unravel the API-DES-Water interactions at a molecular level,
Public release date: 18 November 2022
Principal Investigator: Professor Paulo Ribeiro-Claro
Local Contact: Dr Svemir Rudic
Experimenter: Dr Mariela Nolasco
Experimenter: Miss Catarina Araujo
Experimenter: Dr Carmen Freire
Experimenter: Miss Sónia Pedro
Experimenter: Dr Pedro Duarte Vaz
Experimenter: Dr Carla Vilela
DOI: 10.5286/ISIS.E.RB1920244-1
Parent DOI: 10.5286/ISIS.E.RB1920244
ISIS Experiment Number: RB1920244
Part Number: 1
Date of Experiment: 13 November 2019
Publisher: STFC ISIS Neutron and Muon Source
Data format: RAW/Nexus
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Data Citation
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publication is as:
[author], [date], [title], [publisher],
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For Example:
Professor Paulo Ribeiro-Claro et al; (2019): API-DES: improving drug solubility with deep eutectic solvents, STFC ISIS Neutron and Muon Source, https://doi.org/10.5286/ISIS.E.RB1920244-1